Office Phone: 314-544-5600

4225 Bayless Ave | St. Louis, MO 63123

DEPRESSION AND LOW MOOD

Depression Has Physical Causes That Rarely Get Investigated

The heaviness, the numbness, the loss of interest in things you used to love. You may have been told it is a chemical imbalance and handed a prescription.
Depression | Nepute Wellness
BEYOND THE PRESCRIPTION PAD

Adjusting Neurotransmitters Without Asking Why They Fell Is Incomplete

Antidepressants can be valuable. But prescribing them as a first and only step, without investigating why your brain chemistry shifted, leaves the root cause untouched. Thyroid dysfunction, chronic inflammation, gut dysbiosis, hormone decline, nutrient depletion, and blood sugar instability all produce depressive symptoms. If these go unaddressed, medication alone often.
Hypothyroidism mimics depression and is missed by basic TSH screening
Chronic inflammation triggers depressive pathways in the brain directly
Low vitamin D, B12, and omega-3s are linked to depressive symptoms

Have Questions?

Need help deciding what Product or Solution is a best fit for you? Book a Virtual Consultation with Dr. Nepute!

Explore Potential Treatments

Autonomic Nervous System Analysis
Gut Health & Microbiome Testing
Hormone Testing
Comprehensive Blood Panels
DEPRESSION IS MORE THAN BRAIN CHEMISTRY

The Body Systems That Shape How Your Mind Feels

Neuroscience has moved far beyond the simple serotonin deficiency model. Depression involves the immune system, the endocrine system, the gut microbiome, metabolic function, and nutrient status. Your brain does not operate in isolation. It responds to signals from every system in your body.
— FEATURED RESOURCE —
Health Guides & Protocols

Understanding Stress and Your Body

Research-based guidance on how stress affects your body and practical strategies for building stress resilience, from the National Institute of Mental Health.

Elevated inflammatory cytokines cross the blood-brain barrier and directly alter neurotransmitter metabolism, producing depressive symptoms.

Your gut microbiome produces neurotransmitter precursors and inflammatory signals that profoundly influence mood regulation.

Thyroid, testosterone, estrogen, progesterone, and cortisol each influence neural pathways that regulate motivation, pleasure, and resilience.

WHEN ROOT CAUSES GO UNTESTED

Unaddressed Physical Drivers of Depression Worsen Over Time

Understanding Stress and Your Body
Research-based guidance on how stress affects your body and practical strategies for building stress resilience, from the National Institute of Mental Health.
ROOT CAUSE, NOT SYMPTOM MANAGEMENT

You Deserve a Full Investigation, Not Just a Prescription

If your depression evaluation consisted of a questionnaire and a prescription, critical physical causes may have been overlooked entirely. Our approach runs comprehensive panels: complete thyroid including free T3 and reverse T3, inflammatory markers like hs-CRP and homocysteine, hormone levels, and metabolic markers that standard panels miss entirely.
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RELIEF IS POSSIBLE

Imagine Feeling Like Yourself Again

Picture getting through a full day without the weight of sadness pulling at every moment — choosing how you feel instead of being dragged along by it, reconnecting with the people and things that used to light you up.

Steady Mood

The heaviness eases as the physical drivers behind it are found and addressed.

Depression Fatigue Lifts

Fatigue and brain fog lift as thyroid, nutrient, and metabolic issues are corrected.

Interest Comes Back

Reconnect with the people, work, and activities that used to feel good.

Depression Fog Cleared

Focus and mental sharpness improve as inflammation and blood sugar steady.
Autonomic nervous representation | Nepute Wellness

Autonomic Nervous System Analysis

NERVOUS SYSTEM INTELLIGENCE

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Gut Health & Microbiome Testing

DIGESTIVE AND MICROBIOME ANALYSIS

Hormone testing | Nepute Wellness

Hormone Testing

COMPREHENSIVE HORMONE ASSESSMENT

Blood panel | Nepute Wellness

Comprehensive Blood Panels

ADVANCED DIAGNOSTIC BLOOD CHEMISTRY

PATIENT EXPERIENCES

Others Found Answers Beyond Medication at Nepute Wellness

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Dr. Nepute and his staff are compassionate, kind and truly care about providing the best care! I’ve only been going for a week and I’m very excited to see the improvement in my health.
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Julia Nicholas
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Great atmosphere Staff is super friendly, very knowledgeable and extremely accommodating. No matter how busy they are, you always receive one on one attention. Nepute’s Office is my Family’s primary care provider. 5 children from 18 all the way down to 3. Highly recommend a Dr’s office who absolutely does not help address you like a just another patient who believes that a pill or surgery may help support recovery from all. Believe it or not, our bodies do have the ability to heal themselves. We also actually have our own immune systems that fight against diseases. It’s just a matter of having a Dr who can assist in your personal direction to bring your body’s full potential to flourishing. I’m very happy my wife found Dr Nepute when she did.
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Scottie Kohlberg
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Dr. Nepute is truly a doctor that cares about his patients. He is one of the few Doctor’s that wants to keep his patients healthy instead of keeping them sick! He is highly recommended and makes healthcare what it used to be!
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Judi Gambino
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Mr. Nepute’s chiropractic clinic is a solid place. The staff there are all nice, the people you meet there (from my experiences) have all been friendly and kind. From staff to customers, they make you feel welcome, y’know? Not to mention the staff there are clearly trained, able, and were the right picks for the job. All the chiropractors there are top notch at their jobs, and they’ve helped me make visible progress to helping my issues. Shoutouts to Doctor John. Overall, it’s a great chiropractic experience and I’d recommend it. Friendly people, good services, it’s worth it.
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Zach Oliver
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Dr. Nepute and his staff are AWESOME! Dr. Eric is very gifted in his profession and his heart are his patients. He only wants the best treatment for everyone in a way that God created us to have. His staff is so caring, welcoming and treats you like you are the only one there. They are a fine oiled machine that results in success. God has blessed their practice resulting in so many success stories, but He has also blessed me through divine intervention by placing these wonderful people in my life. I wish everyone can experience the type of God-given treatment we all deserve without having to deal with the bureaucracy of the world that is thrown at us every day of our lives. Thank you Dr. Eric and staff for all you do!
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Lisa Noerper
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Dr. Nepute and his staff make you feel Like family, they really care for their patients. Being apart of the wellness center is a priority for our family!
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Misty Rae Reynolds
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Everyone is so friendly and helpful and knowledgeable! I took my 2 and 4 year old and they were excellent with my children! I love this place! I would highly recommend to everyone. If you have anything wrong they can get to the bottom of it! I’ve had back problems since I was a child and with their help I’ve actually been able to be in minimal pain and actually have reverse damage!
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Maria Hoover
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Dr. Eric Nepute and his staff are exceptional. If you want to get to the root of your health issues, and not just medicate yourself forever, GO SEE DR. E! Regardless of age. My youngest child had digestive and GI issues for years, and after a few months of seeing Dr. Nepute and his staff, my child is healthier, happier and can be a kid again. It doesn’t matter what your health issue is, stress, pain, GI, hormone imbalance, back/neck issues, fatigue, weight gain, cholesterol, high blood pressure, etc. they will get to the bottom of it. I thank God for doctors like Dr. Nepute who are dedicated to HEALTH care, and not just medical care or sick care. They strive to help heal their patients for good, so we don’t have to depend on frequent visits to the doctor for refills and short-term solutions. Thank you Dr. Nepute & Staff. You truly are changing lives every day!
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Jennifer Olson
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Love this office, they always know what to do, and have great results
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Nickole Crites
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Dr. Nepute and his wellness center is absolutely amazing. If you’re looking for an all inclusive approach to getting answers for your health issues, this is where you want to be. Dr. Eric Nepute is extremely knowledgeable and gets to the root cause of the problem. I love the fact that he has multiple sources of ways to help and when he runs a blood work panel, it is very detailed and in depth in which other doctors just don’t do. I feel extremely lucky to have found him and really appreciate that we have someone like him in our area that loves to help people.
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Brenda Larson
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Dr Angelo is great!
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Joy Sauter
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I go there for adjustments weekly and everyone there has a great attitude. I highly recommend it!
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Matt Woods
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The staff was great, I was really impressed, they listen to my concern and gave me excellent care.
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Stephanie Ennis
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My experience was excellent with Nepute Wellness Center. The staff was very nice!
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Anton Arch
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Thank you for your help And I am doing better you are amazing above the others please get a new nurse
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Cynthia Miller
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HOW WE INVESTIGATE DEPRESSION

Looking at the Whole Picture, Not Just the Symptoms

We work alongside any care you already have — never against it. Our role is finding the physical pieces that get overlooked: hormone imbalances, gut dysfunction, nutrient deficiencies, and inflammatory patterns that can quietly fuel how you feel every single day.

Depression | Nepute Wellness
Hypothyroidism mimics depression and is missed by basic TSH screening
Hypothyroidism mimics depression and is missed by basic TSH screening
Depression | Nepute Wellness
Chronic inflammation triggers depressive pathways in the brain directly
Chronic inflammation triggers depressive pathways in the brain directly
Depression | Nepute Wellness
Low vitamin D, B12, and omega-3s are linked to depressive symptoms
Low vitamin D, B12, and omega-3s are linked to depressive symptoms
COMMON QUESTIONS

Frequently Asked Questions About Depression and Physical Health

The Seven Stages of Disconnection is a framework used at Nepute Wellness to help patients understand how health problems develop over time. Rather than viewing symptoms as isolated issues, this mod

Absolutely. Nepute Wellness serves patients from around the world through expanded virtual appointments via Zoom. International patients can access the same level of care, including home-shippable testing kits, virtual consultations (15, 30, or 60 minutes), and recorded Reports of Findings.

For those who prefer an in-person visit, our center is located in St. Louis, Missouri. Our team can help coordinate travel logistics for patients coming from out of state or internationally.

No referral is needed. Nepute Wellness operates outside the traditional insurance-based healthcare model, which means you can schedule directly without a physician referral. Whether you’re local to St. Louis or connecting virtually from anywhere in the world, you can book your consultation through our website.

Simply choose the examination tier that best fits your health needs and budget, and our team will guide you through the rest of the process.

Your first visit to Nepute Wellness is designed to feel warm and family-like, not clinical or intimidating. Depending on your chosen examination tier (Basic, Moderate, or Advanced), you’ll undergo

Nepute Wellness recommends BioLimitless supplement formulas as part of personalized wellness plans. Key formulas include Detox Pro Plus (detoxification support), Master Microbiotics (gut health), C

In-person examination deposits ($50) are non-refundable but may be applied toward rescheduling. Virtual consultation fees are non-refundable once the appointment has taken place. If you need to cancel or reschedule, please contact us at least 24 hours in advance.

BioLimitless products are subject to the BioLimitless return policy. Education materials and training courses are non-refundable once accessed. For full details, visit our Refund & Returns page at neputewellness.com.

Nepute Wellness offers three tiers of virtual one-on-one appointments via Zoom, available to patients worldwide:

  • 15-Minute Quick Hit ($42): Focused check-in or targeted question session
  • 30-Minute Moderate Dive ($242): In-depth review of specific concerns or test results
  • 60-Minute Deep Dive ($420): Comprehensive consultation covering full health assessment

All virtual visits include access to home testing kits that can be shipped directly to you, and your Report of Findings session is recorded so you can review it anytime.

“Selfcare as Healthcare” is one of the guiding mantras at Nepute Wellness. It represents the belief that true healthcare starts with empowering you to take an active role in your own healing and your family’s health, rather than passively depending on the traditional sick-care system.

At Nepute Wellness, this means educating you about root causes, providing tools and resources for ongoing wellness, and giving you the knowledge to make informed decisions about your health journey. Our goal is to move you from confusion and overwhelm to certainty and empowerment.

The Health Investment Plan is how Nepute Wellness frames the cost of care, as an investment in your long-term wellness rather than an expense for managing sickness. During your Day Two Report of Fi

“Blocked, not broken” is a core principle at Nepute Wellness. It means that in many cases, the body isn’t permanently damaged, it’s experiencing interference or blockages that prevent it from funct

Physiology Doesn't Lie:
Symptoms are your body's signals, NOT your diagnoses. Real testing reveals the real cause - and your real path, far away from simply treating those symptoms.
Connect From Anywhere
Expert guidance one-on-one, and without the travel! Limited availability virtual consultations with Dr. Eric Nepute are now available for those who can't visit Nepute Wellness's St. Louis clinic in person.
Cell Signals, Detox Pro Plus & Master Microbiotics
Detox, gut health, and cellular communication. The three pillars of foundational wellness.
Ready to Discover The Root Cause of Your Symptoms?
Comprehensive testing reveals what's actually happening in your body. No more guessing, and no more just "managing your symptoms". Its time to get to the root of your health concerns.
Unlock Your Genetic Blueprint
Your DNA reveals how your body is designed to function. Stop guessing. Start knowing.
Direct Nutrients, Maximum Absorption
You may have heard of a Myer's cocktail or a B-12 injection. At Nepute Wellness, we offer these and more, including custom formulations based on your bodies specific needs.