Office Phone: 314-544-5600

4225 Bayless Ave | St. Louis, MO 63123

YOUR STRESS RESPONSE IS RUNNING

Adrenal Fatigue Is Your Body Telling You the Tank Is Empty

Exhausted but wired. Crashing every afternoon. Relying on caffeine to function and still falling short. A single morning cortisol test will not reveal what is wrong. Comprehensive testing will.
Adrenal fatigue | Nepute Wellness
WHY COFFEE STOPPED WORKING

Your Cortisol Rhythm Is Broken and Nobody Has Measured It

You used to handle stress. Now everything feels like too much. You crash after lunch, cannot fall asleep at night, and rise feeling like you never rested. Your doctor checked your cortisol once, at 8 a.m., and said it was normal. But cortisol follows a rhythm throughout the day.
A single morning cortisol test misses the daily rhythm that matters most
Caffeine masks the problem while further taxing depleted adrenals
Chronic HPA axis dysfunction affects hormones, immunity, and metabolism

Have Questions?

Need help deciding what Product or Solution is a best fit for you? Book a Virtual Consultation with Dr. Nepute!

Explore Potential Treatments

Stress Resilience Evaluation
Hormone Testing
Comprehensive Blood Panels
Heart Rate Variability (HRV) Testing
THE HPA AXIS EXPLAINED

Why Your Stress System Controls More Than You Realize

The hypothalamic-pituitary-adrenal axis is your central stress regulation system. It governs cortisol production, energy distribution, immune response, and sleep cycles. When this axis is dysregulated, the effects cascade through every major body system.
— FEATURED RESOURCE —
Health Guides & Protocols

Understanding Stress and Your Body

Research-based guidance on how stress affects your body and practical strategies for building stress resilience, from the National Institute of Mental Health.

Healthy cortisol peaks in the morning and declines through the day. HPA dysfunction can flatten, invert, or spike this rhythm unpredictably.

When your body prioritizes cortisol production under chronic stress, it diverts resources from thyroid, sex hormone, and immune function.

Prolonged HPA activation eventually leads to blunted output: the adrenals can no longer respond adequately, leaving you depleted and vulnerable.

WHEN ADRENAL DYSFUNCTION IS IGNORED

Running on Empty Does Not Build Resilience, It Erodes It

Understanding Stress and Your Body
Research-based guidance on how stress affects your body and practical strategies for building stress resilience, from the National Institute of Mental Health.
TEST, DON'T GUESS

A Four-Point Cortisol Map Reveals What One Lab Draw Cannot

If nobody has measured your cortisol at multiple points throughout the day, you have not been tested for adrenal dysfunction. You have been screened and missed. Our philosophy is Test, Don't Guess. We map your cortisol rhythm, assess DHEA levels, and evaluate the full HPA axis response.
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ENERGY RESTORED

Imagine Having Your Energy Back

Picture waking up rested and ready instead of exhausted before your feet hit the floor — your energy consistent through the day, your body no longer running on fumes from adrenal reserves it cannot replenish.

Adrenal Energy Restored

Energy that lasts throughout the day without crashes.

Adrenal Even Days

Days without the exhaustion roller coaster.

Stress Capacity

Handle stress without being overwhelmed or depleted.

Adrenal Sleep Restored

Fall asleep easily and wake refreshed. This improvement is supported by identifying and addressing underlying root causes with a personalized care plan.

Resilience Returns

Feel resilient again - able to handle what life throws at you.

Stress Response Decoded

Know exactly what's wrong with your stress response and how you're fixing it.
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Stress Resilience Evaluation

COMPREHENSIVE STRESS RESPONSE TESTING

Hormone testing | Nepute Wellness

Hormone Testing

COMPREHENSIVE HORMONE ASSESSMENT

Blood panel | Nepute Wellness

Comprehensive Blood Panels

ADVANCED DIAGNOSTIC BLOOD CHEMISTRY

Stress resilience testing | Nepute Wellness

Heart Rate Variability (HRV) Testing

AUTONOMIC NERVOUS SYSTEM ASSESSMENT

PATIENT EXPERIENCES

What Patients Say About Adrenal Recovery at Nepute Wellness

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This place is AMAZING ! They actually fix your problems instead of putting bandaids on them . It has truly helped me feel so much better. The doctors are very thorough and take time with you . The nurses and staff are super helpful and ALWAYS friendly ! I highly recommend it !
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Lynn Brock
Google Review
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Friendly staff, Nepute Wellness keeps me going to do the things I want to do. Thanks to ALL of YOU
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Diane Hotard
Google Review
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I look forward to my weekly appointments! With the help of Dr Nepute and other Doctors in his office, I know longer take medication. I was on diabetic meds, high blood pressure and cholesterol. I now just take supplements. His restart program is amazing! I’ve dropped over 100lbs! I recommend him to all of my family and friends!
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elisabeth peeples
Google Review
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Friendly caring staff. Dr Nepute is all about getting you to optimal health.
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Teresa Kelley
Google Review
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Great facility and caring providers. Look forward to going there for my visits.
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Tracy Jaycox
Google Review
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Dr. Nepute is truly a doctor that cares about his patients. He is one of the few Doctor’s that wants to keep his patients healthy instead of keeping them sick! He is highly recommended and makes healthcare what it used to be!
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Judi Gambino
Google Review
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Dr. Nepute and his staff are compassionate, kind and truly care about providing the best care! I’ve only been going for a week and I’m very excited to see the improvement in my health.
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Julia Nicholas
Google Review
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Love this office, they always know what to do, and have great results
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Nickole Crites
Google Review
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Thank you for your help And I am doing better you are amazing above the others please get a new nurse
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Cynthia Miller
Google Review
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The positive experience my family has had with the Nepute wellness Center has been amazing. The level of my families health has increased dramatically, I can’t imagine going anywhere else. I highly recommend!
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Nathan krauss
Google Review
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Doc and his staff are great. Everyone, staff and patients, are ALWAYS smiling and VERY positive. I highly recommend Doc Nepute!
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Gary Chamness
Google Review
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I love this place! Dr Nepute has been beyond kind in helping myself and my son with everything from sports injuries to helping me with my hormones. It warms my heart to see so many families bringing their whole family in. If I could have a do over I would start bringing my children in at a young age. Thank you Nepute Wellness ❤️
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Belleza Salon
Google Review
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I don’t know where to start not only if I get into extreme new version of knowledge about my body but after setting up a long-term plan I’m already seeing results very early in the practice thank you guys so much
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William Duncan
Google Review
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I can’t express how MUCH Nepute Wellness Center has helped me with an onset of arthritis! ALL the treatments have helped tremendously to relieve the pain and discomfort – when I first went there, I couldn’t even stand straight up! Now, I can move about normally. I cannot say enough about all the great people there who are so pleasant and show how much they care about HOW you’re doing! And Dr. Nepute is so knowledgeable, so friendly, so concerned about what’s going on with you. I recommend Nepute Wellness to anyone who does NOT want ‘cookie-cutter’ treatment, but is looking for top-of-the-line care for their health concern by people ‘who REALLY CARE’!
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bobbi s
Google Review
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People are always so polite and helpful. Making you feel comfortable your entire visit. Lots of smiles.
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Kelley Kull
Google Review
HOW WE MAP YOUR STRESS

Multi-Point Cortisol Testing and Full HPA Axis Evaluation

Your adrenal assessment uses four-point cortisol testing throughout the day, DHEA levels, comprehensive hormone panels, blood sugar patterns, and inflammatory markers. We are measuring how depleted your reserves actually are — not guessing from symptoms alone.

Adrenal fatigue | Nepute Wellness
A single morning cortisol test misses the daily rhythm that matters most
A single morning cortisol test misses the daily rhythm that matters most
Adrenal fatigue | Nepute Wellness
Caffeine masks the problem while further taxing depleted adrenals
Caffeine masks the problem while further taxing depleted adrenals
Adrenal fatigue | Nepute Wellness
Chronic HPA axis dysfunction affects hormones, immunity, and metabolism
Chronic HPA axis dysfunction affects hormones, immunity, and metabolism
COMMON QUESTIONS

Frequently Asked Questions About Adrenal Fatigue

The Seven Stages of Disconnection is a framework used at Nepute Wellness to help patients understand how health problems develop over time. Rather than viewing symptoms as isolated issues, this mod

Absolutely. Nepute Wellness serves patients from around the world through expanded virtual appointments via Zoom. International patients can access the same level of care, including home-shippable testing kits, virtual consultations (15, 30, or 60 minutes), and recorded Reports of Findings.

For those who prefer an in-person visit, our center is located in St. Louis, Missouri. Our team can help coordinate travel logistics for patients coming from out of state or internationally.

No referral is needed. Nepute Wellness operates outside the traditional insurance-based healthcare model, which means you can schedule directly without a physician referral. Whether you’re local to St. Louis or connecting virtually from anywhere in the world, you can book your consultation through our website.

Simply choose the examination tier that best fits your health needs and budget, and our team will guide you through the rest of the process.

Your first visit to Nepute Wellness is designed to feel warm and family-like, not clinical or intimidating. Depending on your chosen examination tier (Basic, Moderate, or Advanced), you’ll undergo

Nepute Wellness recommends BioLimitless supplement formulas as part of personalized wellness plans. Key formulas include Detox Pro Plus (detoxification support), Master Microbiotics (gut health), C

In-person examination deposits ($50) are non-refundable but may be applied toward rescheduling. Virtual consultation fees are non-refundable once the appointment has taken place. If you need to cancel or reschedule, please contact us at least 24 hours in advance.

BioLimitless products are subject to the BioLimitless return policy. Education materials and training courses are non-refundable once accessed. For full details, visit our Refund & Returns page at neputewellness.com.

Nepute Wellness offers three tiers of virtual one-on-one appointments via Zoom, available to patients worldwide:

  • 15-Minute Quick Hit ($42): Focused check-in or targeted question session
  • 30-Minute Moderate Dive ($242): In-depth review of specific concerns or test results
  • 60-Minute Deep Dive ($420): Comprehensive consultation covering full health assessment

All virtual visits include access to home testing kits that can be shipped directly to you, and your Report of Findings session is recorded so you can review it anytime.

“Selfcare as Healthcare” is one of the guiding mantras at Nepute Wellness. It represents the belief that true healthcare starts with empowering you to take an active role in your own healing and your family’s health, rather than passively depending on the traditional sick-care system.

At Nepute Wellness, this means educating you about root causes, providing tools and resources for ongoing wellness, and giving you the knowledge to make informed decisions about your health journey. Our goal is to move you from confusion and overwhelm to certainty and empowerment.

The Health Investment Plan is how Nepute Wellness frames the cost of care, as an investment in your long-term wellness rather than an expense for managing sickness. During your Day Two Report of Fi

“Blocked, not broken” is a core principle at Nepute Wellness. It means that in many cases, the body isn’t permanently damaged, it’s experiencing interference or blockages that prevent it from funct

Physiology Doesn't Lie:
Symptoms are your body's signals, NOT your diagnoses. Real testing reveals the real cause - and your real path, far away from simply treating those symptoms.
Connect From Anywhere
Expert guidance one-on-one, and without the travel! Limited availability virtual consultations with Dr. Eric Nepute are now available for those who can't visit Nepute Wellness's St. Louis clinic in person.
Cell Signals, Detox Pro Plus & Master Microbiotics
Detox, gut health, and cellular communication. The three pillars of foundational wellness.
Ready to Discover The Root Cause of Your Symptoms?
Comprehensive testing reveals what's actually happening in your body. No more guessing, and no more just "managing your symptoms". Its time to get to the root of your health concerns.
Unlock Your Genetic Blueprint
Your DNA reveals how your body is designed to function. Stop guessing. Start knowing.
Direct Nutrients, Maximum Absorption
You may have heard of a Myer's cocktail or a B-12 injection. At Nepute Wellness, we offer these and more, including custom formulations based on your bodies specific needs.