Office Phone: 314-544-5600

4225 Bayless Ave | St. Louis, MO 63123

YOUR STRESS RESPONSE IS RUNNING

Adrenal Fatigue Is Your Body Telling You the Tank Is Empty

Exhausted but wired. Crashing every afternoon. Relying on caffeine to function and still falling short. A single morning cortisol test will not reveal what is wrong. Comprehensive testing will.
Adrenal fatigue | Nepute Wellness
WHY COFFEE STOPPED WORKING

Your Cortisol Rhythm Is Broken and Nobody Has Measured It

You used to handle stress. Now everything feels like too much. You crash after lunch, cannot fall asleep at night, and rise feeling like you never rested. Your doctor checked your cortisol once, at 8 a.m., and said it was normal. But cortisol follows a rhythm throughout the day.
A single morning cortisol test misses the daily rhythm that matters most
Caffeine masks the problem while further taxing depleted adrenals
Chronic HPA axis dysfunction affects hormones, immunity, and metabolism

Have Questions?

Need help deciding what Product or Solution is a best fit for you? Book a Virtual Consultation with Dr. Nepute!

Explore Potential Treatments

Stress Resilience Evaluation
Hormone Testing
Comprehensive Blood Panels
Heart Rate Variability (HRV) Testing
THE HPA AXIS EXPLAINED

Why Your Stress System Controls More Than You Realize

The hypothalamic-pituitary-adrenal axis is your central stress regulation system. It governs cortisol production, energy distribution, immune response, and sleep cycles. When this axis is dysregulated, the effects cascade through every major body system.
— FEATURED RESOURCE —
Health Guides & Protocols

Understanding Stress and Your Body

Research-based guidance on how stress affects your body and practical strategies for building stress resilience, from the National Institute of Mental Health.

Healthy cortisol peaks in the morning and declines through the day. HPA dysfunction can flatten, invert, or spike this rhythm unpredictably.

When your body prioritizes cortisol production under chronic stress, it diverts resources from thyroid, sex hormone, and immune function.

Prolonged HPA activation eventually leads to blunted output: the adrenals can no longer respond adequately, leaving you depleted and vulnerable.

WHEN ADRENAL DYSFUNCTION IS IGNORED

Running on Empty Does Not Build Resilience, It Erodes It

Understanding Stress and Your Body
Research-based guidance on how stress affects your body and practical strategies for building stress resilience, from the National Institute of Mental Health.
TEST, DON'T GUESS

A Four-Point Cortisol Map Reveals What One Lab Draw Cannot

If nobody has measured your cortisol at multiple points throughout the day, you have not been tested for adrenal dysfunction. You have been screened and missed. Our philosophy is Test, Don't Guess. We map your cortisol rhythm, assess DHEA levels, and evaluate the full HPA axis response.
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ENERGY RESTORED

Imagine Having Your Energy Back

Picture waking up rested and ready instead of exhausted before your feet hit the floor — your energy consistent through the day, your body no longer running on fumes from adrenal reserves it cannot replenish.

Adrenal Energy Restored

Energy that lasts throughout the day without crashes.

Adrenal Even Days

Days without the exhaustion roller coaster.

Stress Capacity

Handle stress without being overwhelmed or depleted.

Adrenal Sleep Restored

Fall asleep easily and wake refreshed. This improvement is supported by identifying and addressing underlying root causes with a personalized care plan.

Resilience Returns

Feel resilient again - able to handle what life throws at you.

Stress Response Decoded

Know exactly what's wrong with your stress response and how you're fixing it.
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Stress Resilience Evaluation

COMPREHENSIVE STRESS RESPONSE TESTING

Hormone testing | Nepute Wellness

Hormone Testing

COMPREHENSIVE HORMONE ASSESSMENT

Blood panel | Nepute Wellness

Comprehensive Blood Panels

ADVANCED DIAGNOSTIC BLOOD CHEMISTRY

Stress resilience testing | Nepute Wellness

Heart Rate Variability (HRV) Testing

AUTONOMIC NERVOUS SYSTEM ASSESSMENT

PATIENT EXPERIENCES

What Patients Say About Adrenal Recovery at Nepute Wellness

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People are always so polite and helpful. Making you feel comfortable your entire visit. Lots of smiles.
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Kelley Kull
Google Review
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The best wellness center around St louis
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Dhrutika Patel
Google Review
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Very nice Nurses and doctors, ran all my test for low price and multivitamin Intravenous worked really good taking away my foot pain.
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George Smith
Google Review
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Dr. Nepute is truly a doctor that cares about his patients. He is one of the few Doctor’s that wants to keep his patients healthy instead of keeping them sick! He is highly recommended and makes healthcare what it used to be!
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Judi Gambino
Google Review
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Everyone is so professional and so friendly and they do care about your health place is amazing I would recommend anyone to go
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Tina Hammann
Google Review
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Went to Nepute Wellness this afternoon & did I feel great walking out of there. I’ve been getting adjustments & treatment for 10 plus years & what a game changer it’s been. I get Meyer Cocktaiks & B12 shots twice a month. Dr. Eric is the best
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Patti Conger
Google Review
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I want to thank Dr Nepute and his fantastic staff for helpjng me with my concerns and being flexible to help me achive my desired goals
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Peggy Mckinnon
Google Review
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I Always leave feeling great
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Thomas Smith
Google Review
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Absolutely love this doctor. I have went to My Doctor. My medical doctor for 13 years. I progressively got worse. After going to the wellness clinic with Doctor Nepute I started feeling 100% better. Off of three medication. Diabetes is under control. I feel so much better. Best decision I ever made coming to this clinic.
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Google Review
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Kind, caring, informative, and detailed in treatment not leaving a person more confused about what to do next.it’s a nice change from what I’m used to.
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Danielle Campbell
Google Review
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This place is AMAZING ! They actually fix your problems instead of putting bandaids on them . It has truly helped me feel so much better. The doctors are very thorough and take time with you . The nurses and staff are super helpful and ALWAYS friendly ! I highly recommend it !
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Lynn Brock
Google Review
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I have been going to Dr. Nepute’s wellness center for over 4 years now and feel i have greatly benefited from following the plan given to me. I think Dr. Eric really knows what he’s talking about and
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Linda Bronenkamp
Google Review
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Best place ever to get your energy back plus your posture. Everyone that works there is just awesome. Thanks for all they do.
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Richard Pallardy
Google Review
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I’ve been at Nipoti wellness for almost 3 years and my original issue was resolved and I’ve continued to go back for maintenance and other things that pop up as I age. It is great for preventative measures and so much better than going to the doctor after something bad happens! Everyone is friendly and helpful.
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Johnna Wieter
Google Review
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Great atmosphere Staff is super friendly, very knowledgeable and extremely accommodating. No matter how busy they are, you always receive one on one attention. Nepute’s Office is my Family’s primary care provider. 5 children from 18 all the way down to 3. Highly recommend a Dr’s office who absolutely does not help address you like a just another patient who believes that a pill or surgery may help support recovery from all. Believe it or not, our bodies do have the ability to heal themselves. We also actually have our own immune systems that fight against diseases. It’s just a matter of having a Dr who can assist in your personal direction to bring your body’s full potential to flourishing. I’m very happy my wife found Dr Nepute when she did.
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Scottie Kohlberg
Google Review
HOW WE MAP YOUR STRESS

Multi-Point Cortisol Testing and Full HPA Axis Evaluation

Your adrenal assessment uses four-point cortisol testing throughout the day, DHEA levels, comprehensive hormone panels, blood sugar patterns, and inflammatory markers. We are measuring how depleted your reserves actually are — not guessing from symptoms alone.

Adrenal fatigue | Nepute Wellness
A single morning cortisol test misses the daily rhythm that matters most
A single morning cortisol test misses the daily rhythm that matters most
Adrenal fatigue | Nepute Wellness
Caffeine masks the problem while further taxing depleted adrenals
Caffeine masks the problem while further taxing depleted adrenals
Adrenal fatigue | Nepute Wellness
Chronic HPA axis dysfunction affects hormones, immunity, and metabolism
Chronic HPA axis dysfunction affects hormones, immunity, and metabolism
COMMON QUESTIONS

Frequently Asked Questions About Adrenal Fatigue

The Seven Stages of Disconnection is a framework used at Nepute Wellness to help patients understand how health problems develop over time. Rather than viewing symptoms as isolated issues, this mod

Absolutely. Nepute Wellness serves patients from around the world through expanded virtual appointments via Zoom. International patients can access the same level of care, including home-shippable testing kits, virtual consultations (15, 30, or 60 minutes), and recorded Reports of Findings.

For those who prefer an in-person visit, our center is located in St. Louis, Missouri. Our team can help coordinate travel logistics for patients coming from out of state or internationally.

No referral is needed. Nepute Wellness operates outside the traditional insurance-based healthcare model, which means you can schedule directly without a physician referral. Whether you’re local to St. Louis or connecting virtually from anywhere in the world, you can book your consultation through our website.

Simply choose the examination tier that best fits your health needs and budget, and our team will guide you through the rest of the process.

Your first visit to Nepute Wellness is designed to feel warm and family-like, not clinical or intimidating. Depending on your chosen examination tier (Basic, Moderate, or Advanced), you’ll undergo

Nepute Wellness recommends BioLimitless supplement formulas as part of personalized wellness plans. Key formulas include Detox Pro Plus (detoxification support), Master Microbiotics (gut health), C

In-person examination deposits ($50) are non-refundable but may be applied toward rescheduling. Virtual consultation fees are non-refundable once the appointment has taken place. If you need to cancel or reschedule, please contact us at least 24 hours in advance.

BioLimitless products are subject to the BioLimitless return policy. Education materials and training courses are non-refundable once accessed. For full details, visit our Refund & Returns page at neputewellness.com.

Nepute Wellness offers three tiers of virtual one-on-one appointments via Zoom, available to patients worldwide:

  • 15-Minute Quick Hit ($42): Focused check-in or targeted question session
  • 30-Minute Moderate Dive ($242): In-depth review of specific concerns or test results
  • 60-Minute Deep Dive ($420): Comprehensive consultation covering full health assessment

All virtual visits include access to home testing kits that can be shipped directly to you, and your Report of Findings session is recorded so you can review it anytime.

“Selfcare as Healthcare” is one of the guiding mantras at Nepute Wellness. It represents the belief that true healthcare starts with empowering you to take an active role in your own healing and your family’s health, rather than passively depending on the traditional sick-care system.

At Nepute Wellness, this means educating you about root causes, providing tools and resources for ongoing wellness, and giving you the knowledge to make informed decisions about your health journey. Our goal is to move you from confusion and overwhelm to certainty and empowerment.

The Health Investment Plan is how Nepute Wellness frames the cost of care, as an investment in your long-term wellness rather than an expense for managing sickness. During your Day Two Report of Fi

“Blocked, not broken” is a core principle at Nepute Wellness. It means that in many cases, the body isn’t permanently damaged, it’s experiencing interference or blockages that prevent it from funct

Physiology Doesn't Lie:
Symptoms are your body's signals, NOT your diagnoses. Real testing reveals the real cause - and your real path, far away from simply treating those symptoms.
Connect From Anywhere
Expert guidance one-on-one, and without the travel! Limited availability virtual consultations with Dr. Eric Nepute are now available for those who can't visit Nepute Wellness's St. Louis clinic in person.
Cell Signals, Detox Pro Plus & Master Microbiotics
Detox, gut health, and cellular communication. The three pillars of foundational wellness.
Ready to Discover The Root Cause of Your Symptoms?
Comprehensive testing reveals what's actually happening in your body. No more guessing, and no more just "managing your symptoms". Its time to get to the root of your health concerns.
Unlock Your Genetic Blueprint
Your DNA reveals how your body is designed to function. Stop guessing. Start knowing.
Direct Nutrients, Maximum Absorption
You may have heard of a Myer's cocktail or a B-12 injection. At Nepute Wellness, we offer these and more, including custom formulations based on your bodies specific needs.