Office Phone: 314-544-5600

4225 Bayless Ave | St. Louis, MO 63123

DEPRESSION AND LOW MOOD

Depression Has Physical Causes That Rarely Get Investigated

The heaviness, the numbness, the loss of interest in things you used to love. You may have been told it is a chemical imbalance and handed a prescription.
Depression | Nepute Wellness
BEYOND THE PRESCRIPTION PAD

Adjusting Neurotransmitters Without Asking Why They Fell Is Incomplete

Antidepressants can be valuable. But prescribing them as a first and only step, without investigating why your brain chemistry shifted, leaves the root cause untouched. Thyroid dysfunction, chronic inflammation, gut dysbiosis, hormone decline, nutrient depletion, and blood sugar instability all produce depressive symptoms. If these go unaddressed, medication alone often.
Hypothyroidism mimics depression and is missed by basic TSH screening
Chronic inflammation triggers depressive pathways in the brain directly
Low vitamin D, B12, and omega-3s are linked to depressive symptoms

Have Questions?

Need help deciding what Product or Solution is a best fit for you? Book a Virtual Consultation with Dr. Nepute!

Explore Potential Treatments

Autonomic Nervous System Analysis
Gut Health & Microbiome Testing
Hormone Testing
Comprehensive Blood Panels
DEPRESSION IS MORE THAN BRAIN CHEMISTRY

The Body Systems That Shape How Your Mind Feels

Neuroscience has moved far beyond the simple serotonin deficiency model. Depression involves the immune system, the endocrine system, the gut microbiome, metabolic function, and nutrient status. Your brain does not operate in isolation. It responds to signals from every system in your body.
— FEATURED RESOURCE —
Health Guides & Protocols

Understanding Stress and Your Body

Research-based guidance on how stress affects your body and practical strategies for building stress resilience, from the National Institute of Mental Health.

Elevated inflammatory cytokines cross the blood-brain barrier and directly alter neurotransmitter metabolism, producing depressive symptoms.

Your gut microbiome produces neurotransmitter precursors and inflammatory signals that profoundly influence mood regulation.

Thyroid, testosterone, estrogen, progesterone, and cortisol each influence neural pathways that regulate motivation, pleasure, and resilience.

WHEN ROOT CAUSES GO UNTESTED

Unaddressed Physical Drivers of Depression Worsen Over Time

Understanding Stress and Your Body
Research-based guidance on how stress affects your body and practical strategies for building stress resilience, from the National Institute of Mental Health.
ROOT CAUSE, NOT SYMPTOM MANAGEMENT

You Deserve a Full Investigation, Not Just a Prescription

If your depression evaluation consisted of a questionnaire and a prescription, critical physical causes may have been overlooked entirely. Our approach runs comprehensive panels: complete thyroid including free T3 and reverse T3, inflammatory markers like hs-CRP and homocysteine, hormone levels, and metabolic markers that standard panels miss entirely.
Dre | Nepute Wellness
Doclogobluewhite | Nepute Wellness
RELIEF IS POSSIBLE

Imagine Feeling Like Yourself Again

Picture getting through a full day without the weight of sadness pulling at every moment — choosing how you feel instead of being dragged along by it, reconnecting with the people and things that used to light you up.

Steady Mood

The heaviness eases as the physical drivers behind it are found and addressed.

Depression Fatigue Lifts

Fatigue and brain fog lift as thyroid, nutrient, and metabolic issues are corrected.

Interest Comes Back

Reconnect with the people, work, and activities that used to feel good.

Depression Fog Cleared

Focus and mental sharpness improve as inflammation and blood sugar steady.
Autonomic nervous representation | Nepute Wellness

Autonomic Nervous System Analysis

NERVOUS SYSTEM INTELLIGENCE

Stwc guthealth | Nepute Wellness

Gut Health & Microbiome Testing

DIGESTIVE AND MICROBIOME ANALYSIS

Hormone testing | Nepute Wellness

Hormone Testing

COMPREHENSIVE HORMONE ASSESSMENT

Blood panel | Nepute Wellness

Comprehensive Blood Panels

ADVANCED DIAGNOSTIC BLOOD CHEMISTRY

PATIENT EXPERIENCES

Others Found Answers Beyond Medication at Nepute Wellness

Nw bl combo icon sq blk | Nepute Wellness
Everyone is extremely helpful and display a very high level of concern and professionalism.
Show
Pam Davis
Google Review
Nw bl combo icon sq blk | Nepute Wellness
My son, who is only 20, was told by medical professionals that he had an autoimmune liver issue. They wanted to do a liver biopsy. Then, they told him they thought he had a pituitary tumor in his brain that would require brain surgery to remove. A friend recommended Nepute Wellness Center. Dr Nepute was able to diagnose his actual issues in 2 weeks with proper xrays and bloodwork. No autoimmune diseases. No brain tumor. It was a soccer injury from 1.5 yrs prior that had just gotten worse and caused his liver to overwork and a domino effect on his health and organs. We have been going there 3 weeks now and we are both feeling better. My son isn’t tired and can have full range of neck motion. His organ function is back to normal. Thanks Dr Nepute and team! All of you are wonderful!
Show
Jessica Turner
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Dr. Nepute and his staff are AWESOME! Dr. Eric is very gifted in his profession and his heart are his patients. He only wants the best treatment for everyone in a way that God created us to have. His staff is so caring, welcoming and treats you like you are the only one there. They are a fine oiled machine that results in success. God has blessed their practice resulting in so many success stories, but He has also blessed me through divine intervention by placing these wonderful people in my life. I wish everyone can experience the type of God-given treatment we all deserve without having to deal with the bureaucracy of the world that is thrown at us every day of our lives. Thank you Dr. Eric and staff for all you do!
Show
Lisa Noerper
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Everybody was very helpful and polite. They listen and reassure that they was get to problem and give me answer. It team effort. I love how the Athena’s loving and helpful experience. I’m looking to putting my care in their hands.
Show
chris meaders
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Napute Wellness is an efficient and informational CHIROPRACTIC practice. All the staff were professional and helpful. This is the place to be for chiropractic treatment in St. Louis!
Show
Phyllis Gonzalez
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Dr Nepute’s vitamins particularly the D3 and Zinc, have been life changing for me! My blood tests showed a D3 number of a #4…That’s unheard-of low. I took vitamins from Walmart and they did nothing. I took Dr.. Nepute’s vitamins for 2 years, and now my D3 number is a whopping #81. I feel so much better with so much more energy. Thanks Dr. Nepute!
Show
Janie Cohoon
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Went to Nepute Wellness this afternoon & did I feel great walking out of there. I’ve been getting adjustments & treatment for 10 plus years & what a game changer it’s been. I get Meyer Cocktaiks & B12 shots twice a month. Dr. Eric is the best
Show
Patti Conger
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Staff is friendly and very helpful. Dr’s are very knowledgeable, they listen and show that they care. Highly recommend!
Show
Rhonda Lamb
Google Review
Nw bl combo icon sq blk | Nepute Wellness
I’ve been a patient for five years. The staff is second-to-none! It’s a family atmosphere focused on nutrition, supplementation, and getting motion back into your body. I recommend Nepute Wellness to anyone with goals centered on long-term wellness because, as Doc himself reminds his patients: health isn’t only about how you look nor how you feel, but how you function.
Show
Allison Webb
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Dr Nepute is amazing, so knowledgeable, and his team of professionals are so eager to help in any way! I feel blessed to get connected and have hope for my health to vastly improve!
Show
Vicky Abner
Google Review
Nw bl combo icon sq blk | Nepute Wellness
My experience was excellent with Nepute Wellness Center. The staff was very nice!
Show
Anton Arch
Google Review
Nw bl combo icon sq blk | Nepute Wellness
everyone was so nice and was very courteous when working with me
Show
gina loewenstein
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Absolutely worth the drive! The staff is so knowledgeable and they help address you like family. The testing goes way beyond what my primary physician was willing to do because they said it would be too expensive. Absolutely Love this place. Dr. Nepute and his staff are Awesome! Wouldn’t go anywhere else after being seen at Nepute Wellness.
Show
Tammy Bertzyk
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Always friendly and take their time with my needs. Very helpful in answering my questions and work to educate me on how I can take command of my own health.
Show
Bethany Kjellesvik
Google Review
Nw bl combo icon sq blk | Nepute Wellness
Everyone was great, at times they had a lot going on and they might need to have more employees to float around where needed otherwise all is good
Show
michael Shelley
Google Review
HOW WE INVESTIGATE DEPRESSION

Looking at the Whole Picture, Not Just the Symptoms

We work alongside any care you already have — never against it. Our role is finding the physical pieces that get overlooked: hormone imbalances, gut dysfunction, nutrient deficiencies, and inflammatory patterns that can quietly fuel how you feel every single day.

Depression | Nepute Wellness
Hypothyroidism mimics depression and is missed by basic TSH screening
Hypothyroidism mimics depression and is missed by basic TSH screening
Depression | Nepute Wellness
Chronic inflammation triggers depressive pathways in the brain directly
Chronic inflammation triggers depressive pathways in the brain directly
Depression | Nepute Wellness
Low vitamin D, B12, and omega-3s are linked to depressive symptoms
Low vitamin D, B12, and omega-3s are linked to depressive symptoms
COMMON QUESTIONS

Frequently Asked Questions About Depression and Physical Health

The Seven Stages of Disconnection is a framework used at Nepute Wellness to help patients understand how health problems develop over time. Rather than viewing symptoms as isolated issues, this mod

Absolutely. Nepute Wellness serves patients from around the world through expanded virtual appointments via Zoom. International patients can access the same level of care, including home-shippable testing kits, virtual consultations (15, 30, or 60 minutes), and recorded Reports of Findings.

For those who prefer an in-person visit, our center is located in St. Louis, Missouri. Our team can help coordinate travel logistics for patients coming from out of state or internationally.

No referral is needed. Nepute Wellness operates outside the traditional insurance-based healthcare model, which means you can schedule directly without a physician referral. Whether you’re local to St. Louis or connecting virtually from anywhere in the world, you can book your consultation through our website.

Simply choose the examination tier that best fits your health needs and budget, and our team will guide you through the rest of the process.

Your first visit to Nepute Wellness is designed to feel warm and family-like, not clinical or intimidating. Depending on your chosen examination tier (Basic, Moderate, or Advanced), you’ll undergo

Nepute Wellness recommends BioLimitless supplement formulas as part of personalized wellness plans. Key formulas include Detox Pro Plus (detoxification support), Master Microbiotics (gut health), C

In-person examination deposits ($50) are non-refundable but may be applied toward rescheduling. Virtual consultation fees are non-refundable once the appointment has taken place. If you need to cancel or reschedule, please contact us at least 24 hours in advance.

BioLimitless products are subject to the BioLimitless return policy. Education materials and training courses are non-refundable once accessed. For full details, visit our Refund & Returns page at neputewellness.com.

Nepute Wellness offers three tiers of virtual one-on-one appointments via Zoom, available to patients worldwide:

  • 15-Minute Quick Hit ($42): Focused check-in or targeted question session
  • 30-Minute Moderate Dive ($242): In-depth review of specific concerns or test results
  • 60-Minute Deep Dive ($420): Comprehensive consultation covering full health assessment

All virtual visits include access to home testing kits that can be shipped directly to you, and your Report of Findings session is recorded so you can review it anytime.

“Selfcare as Healthcare” is one of the guiding mantras at Nepute Wellness. It represents the belief that true healthcare starts with empowering you to take an active role in your own healing and your family’s health, rather than passively depending on the traditional sick-care system.

At Nepute Wellness, this means educating you about root causes, providing tools and resources for ongoing wellness, and giving you the knowledge to make informed decisions about your health journey. Our goal is to move you from confusion and overwhelm to certainty and empowerment.

The Health Investment Plan is how Nepute Wellness frames the cost of care, as an investment in your long-term wellness rather than an expense for managing sickness. During your Day Two Report of Fi

“Blocked, not broken” is a core principle at Nepute Wellness. It means that in many cases, the body isn’t permanently damaged, it’s experiencing interference or blockages that prevent it from funct

Physiology Doesn't Lie:
Symptoms are your body's signals, NOT your diagnoses. Real testing reveals the real cause - and your real path, far away from simply treating those symptoms.
Connect From Anywhere
Expert guidance one-on-one, and without the travel! Limited availability virtual consultations with Dr. Eric Nepute are now available for those who can't visit Nepute Wellness's St. Louis clinic in person.
Cell Signals, Detox Pro Plus & Master Microbiotics
Detox, gut health, and cellular communication. The three pillars of foundational wellness.
Ready to Discover The Root Cause of Your Symptoms?
Comprehensive testing reveals what's actually happening in your body. No more guessing, and no more just "managing your symptoms". Its time to get to the root of your health concerns.
Unlock Your Genetic Blueprint
Your DNA reveals how your body is designed to function. Stop guessing. Start knowing.
Direct Nutrients, Maximum Absorption
You may have heard of a Myer's cocktail or a B-12 injection. At Nepute Wellness, we offer these and more, including custom formulations based on your bodies specific needs.